Abstract: Gas liquid separation performance of a multi-tube axial cyclone separator with different structural guide vanes was studied. Effects of guide vane type, outlet angle/number on pressure drop and gas liquid separation efficiency were investigated. In addition, the separation performance of the separator with different guide vanes was compared and analyzed. Finally, effects of air intake in inlet chamber on separation efficiency were investigated with preferred guide vane. The experimental results show that blade outlet angle is the main factor affecting resistance characteristics of the separator comparing to blade numbers. When the concentration is below the critical concentration, the separation efficiency increases with the increase of concentration under high inlet flow and small outlet angle. Vertical slit gas extraction in low liquid concentration region is beneficial for separation. With different combination of structural parameters and vertical slit gas extraction, a blade selection diagram based on inlet flow rate and gas content is obtained.