Abstract: Camptothecine solubility in dimethylsulfoxide-methanol/ethanol mixed solvents was measured over temperature range of 274.50~326.00 K under atmospheric pressure. The experimental results show that the solubility of camptothecine in the mixed solvents increases with the increase of temperature and dimethylsulfoxide mole fraction. The experimental solubility data are well correlated with a modified Apelblat equation, λh equation and ideal equation, respectively. The Akaike's Information Criterion (AIC) was used to select the best model for correlation. The dissolution enthalpy, entropy and Gibbs free energy change of camptothecine are calculated using the measured solubility.