Abstract: The ordered mesoporous silica zeolite (SBA-15) was used as support to prepare Cu-supported catalyst for improving the activity, selectivity and stability of Cu-based catalysts. Cu-La₂O₃-Al₂O₃/SBA-15 catalyst was prepared by simple co-impregnation method and applied to catalytic upgrading of ethanol to n-butanol reaction in a fixed-bed reactor. Under the reaction conditions of 533 K, 3 MPa, liquid hourly space velocity (LHSV)=2 mL·h^-1·g^-1 and V(N₂)/ V(EtOH)=250:1, the catalyst exhibited 46.8% ethanol conversion and 48.9% n-butanol selectivity, and showed excellent stability in 120 h on-stream evaluation. The highly dispersed Al₂O₃ and La₂O₃ species on the SBA-15 support provided a large number of acid-base sites which can efficiently promote aldol condensation of acetaldehyde, while the highly dispersed and stable Cu species provided a large number of dehydrogenation/hydrogenation sites. The synergy of the Cu and acid-base sites is responsible for the excellent catalytic properties of Cu-La₂O₃-Al₂O₃/SBA-15 catalyst.