Abstract: A heat-pump-assisted pressure-swing reactive distillation integrated process was proposed to address the pinch point in the n-propanol/n-propyl propionate binary system and the high separation energy consumption during the preparation of n-propyl propionate via esterification of propionic acid with excess n-propanol. The intrinsic kinetic experimental data for the reaction were measured, and the kinetic model parameters were regressed using D005-IIS resin as the catalyst. The operating pressures of the reactive distillation column and the separation distillation column were determined by thermodynamic analysis of the reaction system, and a pressure-swing reactive distillation process was designed. On this basis, heat pump and heat integration were used to further intensify the pressure-swing reactive distillation process. The energy-saving performance of three process schemes was compared using composite curves, followed by analyses of energy consumption, total annual cost （TAC）, and thermodynamic efficiency were carried out. Compared with the pressure-swing reactive distillation process, the overhead vapor recompression-based pressure-swing reactive distillation heat-integrated process recovered 1.7 MW of waste heat, decreased energy consumption by 34.67%, lowered TAC by 4.2%, and raised thermodynamic efficiency from 7.84% to 14.31%. These results indicate that there are substantial energy, environmental, and economic advantages to the heat-pump-assisted pressure-swing reactive distillation integrated process.