Abstract: In order to provide technical guidance for mixing intensification of high energetic material preparation in microreactors, effects of inert gas and ultrasound were studied to determine the segregation index of Villermaux-Dushman reaction, and the mixing performance of the microreactors was assessed under different gas-liquid inlet velocities, gas-liquid ratios, and ultrasonic field intensities.Furthermore, computational fluid dynamics methods were employed to couple fluid flow, chemical reactions, two-phase flow-field, and pressure acoustics to numerically investigate the effects of gas-liquid ratio and ultrasonic power on the segregation index of Villermaux-Dushman reaction.The mechanism of intensification of gas-liquid two phase reaction systems and flow regime transition point were elucidated.The research results can contribute to the design optimization of gas-liquid two-phase flow microreactors.