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    α-酮戊二酸在3种溶剂及其丙酮酸混合溶液中的溶解度测定及关联

    Measurement and correlation of solubility of α-ketoglutarate in three solvents and their pyruvate mixed solutions

      摘要
    • 摘要: 采用静态法测定了常压下α-酮戊二酸在水、乙酸乙酯、乙酸正丁酯和丙酮酸中的溶解度, 并研究了丙酮酸对α-酮戊二酸在水、乙酸乙酯、乙酸正丁酯3种溶剂中溶解度的影响。实验结果表明: α-酮戊二酸在水-丙酮酸、乙酸乙酯-丙酮酸、乙酸正丁酯-丙酮酸3种混合溶剂中的溶解度总体与温度呈正相关; 在水-丙酮酸混合溶剂中, 丙酮酸摩尔比(y1)增大会使α-酮戊二酸的溶解度减小; 在乙酸乙酯-丙酮酸、乙酸正丁酯-丙酮酸混合体系中, 丙酮酸摩尔比增加会使α-酮戊二酸的溶解度先减小后增大, 两体系极小值分别位于乙酸乙酯-丙酮酸摩尔比y2=0.60和乙酸正丁酯-丙酮酸摩尔比y3=0.47附近。Apelblat方程、Yaws方程和(CNIBS)/Redlich-Kister方程对α-酮戊二酸在以上3种混合溶剂中的溶解度数据关联良好; 采用修正的van't Hoff方程计算了α-酮戊二酸在水-丙酮酸、乙酸乙酯-丙酮酸、乙酸正丁酯-丙酮酸3种混合体系的溶解焓、溶解熵和吉布斯自由能。研究结果为建立α-酮戊二酸的生产工艺提供基础数据。

       

      Abstract: The solubility of α-ketoglutarate(α-KG) in water, ethyl acetate (EA), n-butyl acetate (nBA) and pyruvate (PYR) under normal pressure was determined by a static method.Effects of PYR on the solubility of α-KG in water, EA and nBA was studied.The results show that the solubility of α-KG in water-PYR, EA-PYR and nBA-PYR is positively correlated with temperature.In water-PYR mixture solvents, the solubility of α-KG decreases with the increase of the molar ratio of pyruvate (y1).In the EA-PYR and nBA-PYR mixed solvents, the solubility decreases first and then increases with the increase of the molar ratio of PYR, and the minimum values are near y2=0.60 and y3=0.47, respectively.Apelblat model, Yaws model and (CNIBS)/Redlich-Kister equation correlate well with the solubility data of α-KG in the three mixed solvents.The Thermodynamic parameters (ΔsolH°m, ΔsolS°m and ΔsolG°m) of α-KG in above three systems were calculated by modified van't Hoff equation.

       

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