Abstract: Heterogeneous wetting behavior ubiquitous exist on surfaces.In order to investigate the wetting characteristics, seven millimeter-scale striped polytetrafluoroethylene (PFA)-Cu surfaces with different relative hydrophobicity were prepared by coating technology and mechanical processing method.Three-dimensional visualization experimental platform was established by depositing droplets at zero velocity.Effects of droplet volume and deposition position were investigated.The results indicate that with the increasing droplet volume, the droplet undergoes a uniform—nonuniform—uniform wetting process.The width of the hydrophilic region plays a decisive role.When the ratio of droplet diameter to the width of the hydrophilic region is less than 8, anisotropic wetting is observed.However, isotropic wetting occurs with the ratio greater than 8, which is in good agreement with the Cassie model.This research enriches the wetting data on striped surfaces and provide a basis for functional surface design in related fields.