Abstract: In order to investigate the effect of the flow rate, preheating temperature and concentration of VOCs（volatile organic compounds） in coal chemical industry on the temperature and conversion rate of the catalytic oxidation reactor, as well as the coupling effect of multiple factors, this study focuses on a catalytic oxidation reactor for VOCs. A combined approach of experimental investigation via a VOCs catalytic tube furnace and MATLAB-based one-dimensional modeling of the catalytic reactor was employed to calibrate kinetic parameters. Systematic investigations were conducted through single-factor analysis and Box-Behnken response surface experimental design to explore the individual and combined effects of preheating temperature, flow rate, and concentration on reactor temperature and VOCs conversion efficiency. The results demonstrate that the response surface model based on Box-Behnken design has revealed nonlinear interactions among the three factors. Near the central parameter levels, the sensitivity order for reactor temperature was VOCs concentration > preheating temperature > exhaust flow rate, while for conversion efficiency, it was preheating temperature > exhaust flow rate > VOCs concentration. By integrating coupling equations with sensitivity analysis, and targeting reactor temperature <550 ℃ and VOCs conversion > 97%, a theoretically feasible region for preheating temperature was determined using the exhaust flow rate and VOCs concentration as input parameters. This study provides theoretical guidance for parameter optimization and control in industrial VOCs catalytic oxidation reactors.