Abstract: A synthetic process was proposed to obtain 6-(2, 6-difluorophenyl)-5-fluoropicolinic acid (compound 1), the intermediate of N-(4-((1R, 3S, 5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl) -6-(2, 6-difluorophenyl)-5-fluoropicolinamide (PIM447), from 5-fluoropicolinic acid (compound 2) through oxidation, chlorination, halo-exchange, esterification, Suzuki coupling, hydrolysis reactions. 2-Carboxy-5-fluoropyridine-N-oxide (compound 3) was prepared by the oxidation reaction of compound 2 with H₂O₂, 6-chloro-5-fluoropicolinic acid (compound 4) by chlorination reaction of compound 3 with POCl₃, 6-bromo-5-fluoropicolinic acid (compound 5) by halo-exchange reaction of compound 4 in HBr-HOAc solution, methyl 6-bromo-5-fluoropicolinate (compound 6) by the esterification of compound 5 with MeOH, and methyl 6-(2, 6-difluorophenyl)-5-fluoropicolinate (compound 7) by Suzuki cross-coupling between compound 6 and (2, 6-difluorophenyl)boronic acid. Compound 1 was finally synthesized by hydrolysis of compound 7 with NaOH/MeOH solution with a total yield of 58.7%.